Cannon Street does not play a large role in the “The Man with The Twisted Lip” except for serving as the center of Neville St. Clair’s  ventures. The train station is how he gets to and from opium. Before he was a wealthy, employed, respected Englishman, he would travel into town and return via Cannon Street at 5.14 each day due to his interest in companies in that area. This establishes St. Clair as an honest hardworking London citizen who spent long hours in town looking for work until he attained his objectives. In contrast to Mr. St. Clair’s 37 year old self, who spends time near Fresno Street and Upper Swandam Lane at opium dens, he was driven as a young man. Ironically, St. Clair establishes himself in the neighborhood near Cannon Street and this is also the neighborhood of his downfall.

According to the Charles Booth Online Archive the area surrounding Cannon Street was chronically poor and struggling.Old Bailey Online records that the majority of crimes were theft, peace disturbance, and deception. Deception is particularly relevant to “The Man with the Twisted Lip” because in the same way that St. Clair adjusted to the business district as a young man is the same way in which he disguised himself in the crowds of East London and opium dens except this instance was deceitful and harmful.